品系特点
同源品系
  
靶向突变
  
原始参考文献
Info 当使用该小鼠品系发表文献时,请引用原始参考文献,并在材料方法中注明该品系的品系货号:JAX stock #002207
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品系捐赠者 杰克森实验室小鼠资源库 - 杰克森实验室
  
品系详情
此品系Ldlrtm1Her 突变纯合小鼠的血清胆固醇水平升高至200-400 mg/dL;如饲喂高脂饲料,其血清胆固醇水平将会非常高 (>2,000 mg/dL)。小鼠血清胆固醇的正常水平为80-100 mg/dL。
品系建立
Ldlrtm1Her 突变品系由德克萨斯大学达拉斯西南医学中心霍华德·休斯医学研究所研究实验室的Robert Hammer博士和Joachim Herz博士实验室建立。将新霉素耐药基因片段插入4号外显子后,预计可编码截短的非功能性蛋白,该蛋白不会结合LDL,并且不含跨膜片段。在品系建立过程中,使用了源自129的AB1 ES细胞系。此品系已与 C57BL/6J小鼠回交10代(N10)。
参考文献
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在文献发表时若用到该小鼠品系,请引用原文,并在文章的材料与方法部分注明JAX品系号017009。


1993

Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery [see comments]

Ishibashi S , et al.

PubMed:8349823

MGI:J:37394

J Clin Invest 92(2):883-93

其它参考文献
2004

Defective VLDL metabolism and severe atherosclerosis in mice expressing human apolipoprotein E isoforms but lacking the LDL receptor.

Knouff C , et al.

PubMed:15450205
MGI:J:92554
Biochim Biophys Acta 1684(1-3):8-17
2004

Elevation of plasma phospholipid transfer protein increases the risk of atherosclerosis despite lower apolipoprotein B-containing lipoproteins.

Lie J , et al.

PubMed:14993244
MGI:J:89308
J Lipid Res 45(5):805-11
2004

Diabetes and diabetes-associated lipid abnormalities have distinct effects on initiation and progression of atherosclerotic lesions.

Renard CB , et al.

PubMed:15343384
MGI:J:92597
J Clin Invest 114(5):659-68
2004

Participation of macrophages in atherosclerotic lesion morphology in LDLr-/- mice.

Schiller NK , et al.

PubMed:15175354
MGI:J:91367
J Lipid Res 45(8):1398-409
2004

Effect of macrophage-derived apolipoprotein E on hyperlipidemia and atherosclerosis of LDLR-deficient mice.

Shi W , et al.

PubMed:15047172
MGI:J:88891
Biochem Biophys Res Commun 317(1):223-9
2004

Novel QTLs for HDL levels identified in mice by controlling for Apoa2 allelic effects: confirmation of a chromosome 6 locus in a congenic strain.

Welch CL , et al.

PubMed:14722362
MGI:J:88731
Physiol Genomics 17(1):48-59
2003

Pneumococcal vaccination decreases atherosclerotic lesion formation: molecular mimicry between Streptococcus pneumoniae and oxidized LDL.

Binder CJ , et al.

PubMed:12740573
MGI:J:83726
Nat Med 9(6):736-43
2002

Microsomal Triacylglycerol Transfer Protein Is Required for Lumenal Accretion of Triacylglycerol Not Associated with ApoB, as Well as for ApoB Lipidation.

Kulinski A , et al.

PubMed:12072432
MGI:J:78774
J Biol Chem 277(35):31516-25
2002

LDL receptor but not apolipoprotein E deficiency increases diet-induced obesity and diabetes in mice.

Schreyer SA , et al.

PubMed:11739102
MGI:J:75609
Am J Physiol Endocrinol Metab 282(1):E207-14
2002

Loss of Lymphotoxin-alpha but Not Tumor Necrosis Factor-alpha Reduces Atherosclerosis in Mice.

Schreyer SA , et al.

PubMed:11809756
MGI:J:75788
J Biol Chem 277(14):12364-8
2002

Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues.

van Eck M , et al.

PubMed:11972062
MGI:J:76337
Proc Natl Acad Sci U S A 99(9):6298-303
2002

Macrophage-specific expression of class A scavenger receptors in LDL receptor(-/-) mice decreases atherosclerosis and changes spleen morphology.

Whitman SC , et al.

PubMed:12177164
MGI:J:78922
J Lipid Res 43(8):1201-8
2001

Compared with saturated fatty acids, dietary monounsaturated fatty acids and carbohydrates increase atherosclerosis and VLDL cholesterol levels in LDL receptor-deficient, but not apolipoprotein E-deficient, mice.

Merkel M , et al.

PubMed:11606787
MGI:J:72580
Proc Natl Acad Sci U S A 98(23):13294-9
2001

Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E.

Tangirala RK , et al.

PubMed:11024044
MGI:J:66833
J Biol Chem 276(1):261-6
2001

Localization of atherosclerosis susceptibility loci to chromosomes 4 and 6 using the Ldlr knockout mouse model.

Welch CL , et al.

PubMed:11438740
MGI:J:70259
Proc Natl Acad Sci U S A 98(14):7946-51
2000

Macrophage lipoprotein lipase promotes foam cell formation and atherosclerosis in low density lipoprotein receptor-deficient mice

Babaev VR , et al.

PubMed:10858435
MGI:J:64000
J Biol Chem 275(34):26293-9
2000

Increased LDL cholesterol and atherosclerosis in LDL receptor-deficient mice with attenuated expression of scavenger receptor B1.

Huszar D , et al.

PubMed:10764675
MGI:J:62371
Arterioscler Thromb Vasc Biol 20(4):1068-73
2000

Effect of hyperglycemia and hyperlipidemia on atherosclerosis in LDL receptor-deficient mice: establishment of a combined model and association with heat shock protein 65 immunity.

Keren P , et al.

PubMed:10866061
MGI:J:62295
Diabetes 49(6):1064-9
2000

Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice [see comments]

Schonbeck U , et al.

PubMed:10861012
MGI:J:63076
Proc Natl Acad Sci U S A 97(13):7458-63
2000

Analysis of low-density lipoprotein catabolism by primary cultures of hepatic cells from normal and low-density lipoprotein receptor knockout mice.

Truong TQ , et al.

PubMed:10760479
MGI:J:61821
Biochim Biophys Acta 1484(2-3):307-15
1995

Initial hepatic removal of chylomicron remnants is unaffected but endocytosis is delayed in mice lacking the low density lipoprotein receptor.

Herz J , et al.

PubMed:7753850
MGI:J:25195
Proc Natl Acad Sci U S A 92(10):4611-5
1994

Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice.

Ishibashi S , et al.

PubMed:8182121
MGI:J:77012
J Clin Invest 93(5):1885-93
1994

The two-receptor model of lipoprotein clearance: tests of the hypothesis in knockout mice lacking the low density lipoprotein receptor, apolipoprotein E, or both proteins.

Ishibashi S , et al.

PubMed:8183926
MGI:J:18138
Proc Natl Acad Sci U S A 91(10):4431-5
等位基因参考文献
基因分型和繁育
Allele Symbol Ldlr<tm1Her>
Allele Specific Protocols
  
Ldlrtm1Her品系通过纯合同胞兄弟姐妹交配来维持。目前仅可订购纯合小鼠。
繁育策略
纯合雌鼠 X 纯合雄鼠
外观
详情

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Related Genotype: a/a

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002207
Ldlr KO
代谢疾病、心血管疾病、糖尿病与肥胖症研究