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原始参考文献
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品系详情
DBA/2J小鼠是一种广泛使用并极具研究价值的近交品系，其应用领域包括心血管生物学、神经生物学和感觉神经研究。 此品系的特点通常与C57BL/6J近交品系（品系货号：000664）形成对比。 DBA/2J小鼠在接受致动脉粥样硬化饮食（1.25%胆固醇、0.5%胆酸和15%脂肪）14周后，表现出对动脉粥样硬化病变的低易感性（20到350um2动脉粥样硬化病变/主动脉横截面）。此外，DBA/2J 小鼠大约在离乳/青春期（3-4周龄）开始出现高频听力丧失，并在2-3月龄时发展为重度听力丧失。 在1951-1975年期间，DBA/2J小鼠品系出现了自发的年龄相关性听力丧失8突变。 该品系具有三种可引起进展性耳蜗病状的隐性等位基因，最初影响柯蒂氏器。 随着前腹侧耳蜗核体积减小和神经元损失，周围性听力丧失出现同步进展。 年轻DBA/2J近交系小鼠携带asp2突变，因此也容易发生听源性惊厥，然而这种易感性会随着小鼠成年而降低。许多DBA/2J小鼠都会发展为钙化性心包炎，睾丸、舌头和骨骼肌均可见钙化病变。 此品系对植物血凝素反应最弱 (Heiniger et al, 1975)，但对氟哌啶醇高度敏感 (kane et al, 1993)。
DBA/2J小鼠随着衰老逐渐出现进展性眼部异常，与人类遗传性青光眼非常相似。 眼部异常包括虹膜色素分散、虹膜萎缩、虹膜前粘连（虹膜与角膜粘连）和眼压升高 (IOP)。 DBA/2J小鼠从3-4个月龄开始出现疾病症状，56%的雌鼠和15%的雄鼠在此时出现虹膜色素上皮细胞丢失和周边虹膜透光的表现。 到6-7月龄时，所有小鼠都表现出明显的广泛透光和虹膜边界增厚。 部分雌鼠在6月龄时眼压明显升高。 到9月龄时，雌雄小鼠均表现出眼压升高，其中雌鼠（平均值： 20.3 +/- 1.8 mmHg）高于雄鼠（平均值： 16.2 +/- 1.4 mmHg）。 视网膜组织病理学显示视网膜神经节细胞、γ-氨基丁酸 (GABA) 能神经元和胆碱能无长突细胞丢失 (Moon et al, 2005)。 GpnmbR150X和Tyrp1isa等位基因都存在于DBA/2J小鼠中，共同促进了小鼠的眼睛表型。
此外，DBA/2J小鼠由于自发的Taar1m1J点突变表现出甲基苯丙胺亲和性，但对酒精和吗啡极度不耐受 (Belknap et al, 1993)。 2002年，Vance等报道了DBA/2J小鼠NK细胞的特点，即缺乏CD94/NKG2A受体的表面表达。CD94/NKG2受体通常表达于大多数胎儿NK细胞的表面。 认为CD94/NKG2的表达与NK细胞自身耐受和区分MHC I类分子低/高表达靶细胞的能力有关。CD94是小鼠Klrd1位点的产物，该基因位于小鼠6号染色体。 Wilhelm及其同事随后发表了一篇文章 (Wilhelm et al, 2003)，在其中报道了DBA/2J小鼠Klrd1基因3'末端的缺失。 这个约2.4 kb的缺失并不影响基因的转录，但会阻碍CD94蛋白的翻译和细胞表面表达。 对杰克森实验室保存的DNA样本的分析（结果未发表）证实了DBA/2J品系中存在Klrd1缺失。 该缺失发生于1984年至1989年之间，在我们的鼠群中为纯合子，这使得DBA/2J 小鼠天生缺乏 CD94。
品系建立
DBA近交品系是最古老的近交小鼠品系。1909 年，CC Little博士从一个根据被毛颜色分离的鼠群开始近亲交配。 在1929年和1930年进行亚系杂交，建立了包含DBA/1和 DBA/2在内的多个新亚系。DBA/1和DBA/2在多个位点上存在差异（包括MHC H2单倍型），这很可能是分离亚系时品系中残留杂合性的结果。
参考文献
精选参考文献
在文章发表时，如使用了该品系，请引用原始文献，并在材料与方法部分注明JAX品系号000671。
2017

A Spontaneous Mutation in Taar1 Impacts Methamphetamine-Related Traits Exclusively in DBA/2 Mice from a Single Vendor.

Reed C , et al.

PubMed:29403379

MGI：J：84847

Front Pharmacol 8:993

2017

Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains.

Timmermans S , et al.

PubMed:28784771

MGI:J:244295

Proc Natl Acad Sci U S A 114(34):9158-9163

2013

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.

Howell GR , et al.

PubMed:23806181

MGI:J:199369

J Neuroinflammation 10(1):76

 
2013

Retinal ganglion cell dendritic atrophy in DBA/2J glaucoma.

Williams PA , et al.

PubMed:23977271

MGI:J:199858

PLoS One 8(8):e72282

 
2013

Deficiency of complement component 5 ameliorates glaucoma in DBA/2J mice.

Howell GR , et al.

PubMed:23806181

MGI:J:199369

J Neuroinflammation 10(1):76

 
2008

Mouse genetic models: an ideal system for understanding glaucomatous neurodegeneration and neuroprotection.

Howell GR , et al.

PubMed:18929118

MGI:J:140472

Prog Brain Res 173:303-21

 
2004

Development of a SNP genotyping panel for genetic monitoring of the laboratory mouse.

Petkov PM , et al.

PubMed:15081119

MGI:J:89298

Genomics 83(5):902-11

 
2002

Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice.

Anderson MG , et al.

PubMed:11743578

MGI:J:75398

Nat Genet 30(1):81-5

 
2001

Genetic loci determining bone density in mice with diet-induced atherosclerosis.

Drake TA , et al.

PubMed:11328966

MGI:J:69682

Physiol Genomics 5(4):205-15

 
1995

Hyper- and hypo-responsiveness to dietary fat and cholesterol among inbred mice: searching for level and variability genes.

Kirk EA , et al.

PubMed:7595076

MGI:J:28648

J Lipid Res 36(7):1522-32

 
1995

Genetics of responsiveness to high-fat and high- cholesterol diets in the mouse.

Paigen B , et al.

PubMed:7625360
MGI:J:28248
Am J Clin Nutr 62(2):458S-462S
 
1993

On the relationship between D2 receptor density and neuroleptic-induced catalepsy among eight inbred strains of mice.

Kanes SJ , et al.

PubMed:7901398
MGI:J:16201
J Pharmacol Exp Ther 267(1):538-47
 
1993

Atherosclerosis and plasma and liver lipids in nine inbred strains of mice.

Nishina PM , et al.

PubMed:8355588
MGI:J:13267
Lipids 28(7):599-605
 
1990

Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice.

Paigen B , et al.

PubMed:2317166
MGI:J:22615
Arteriosclerosis 10(2):316-23
 
1985

Variation in susceptibility to atherosclerosis among inbred strains of mice.

Paigen B , et al.

PubMed:3841001
MGI:J:109950
Atherosclerosis 57(1):65-73
 
其它参考文献
2011
Mouse genomic variation and its effect on phenotypes and gene regulation.
Keane TM , et al.
PubMed:21921910
MGI:J:177037
Nature 477(7364):289-94
2007
Mouse behavioral tasks relevant to autism: phenotypes of 10 inbred strains.
Moy SS , et al.
PubMed:16971002
MGI:J:138682
Behav Brain Res 176(1):4-20
2004
Strain distribution pattern of susceptibility to immune-mediated nephritis.
Xie C , et al.
PubMed:15067087
MGI:J:122988
J Immunol 172(8):5047-55
2003
Allergen-induced airway disease is mouse strain dependent.
Whitehead GS , et al.
PubMed:12626335
MGI:J:84265
Am J Physiol Lung Cell Mol Physiol 285(1):L32-42
2000
Differential maintenance and frequency-dependent tuning of LTP at hippocampal synapses of specific strains of inbred mice.
Nguyen PV , et al.
PubMed:11067991
MGI:J:71278
J Neurophysiol 84(5):2484-93
2000
Macronutrient diet selection in thirteen mouse strains.
Smith BK , et al.
PubMed:10749765
MGI:J:61602
Am J Physiol Regul Integr Comp Physiol 278(4):R797-805
1999
Interacting loci cause severe iris atrophy and glaucoma in DBA/2J mice.
Chang B , et al.
PubMed:10192392
MGI:J:54013
Nat Genet 21(4):405-9
1998
Essential iris atrophy, pigment dispersion, and glaucoma in DBA/2J mice [published erratum appears in Invest Ophthalmol Vis Sci 1998 Aug;39(9):1641]
John SW , et al.
PubMed:9579474
MGI:J:47302
Invest Ophthalmol Vis Sci 39(6):951-62
1998
Exposure to an augmented acoustic environment alters auditory function in hearing-impaired DBA/2J mice.
Turner JG , et al.
PubMed:9606065
MGI:J:47560
Hear Res 118(1-2):101-13
1996
Morphological changes in the anteroventral cochlear nucleus that accompany sensorineural hearing loss in DBA/2J and C57BL/6J mice.
Willott JF , et al.
PubMed:8852372
MGI:J:32170
Brain Res Dev Brain Res 91(2):218-26
1993
Voluntary consumption of morphine in 15 inbred mouse strains.
Belknap JK , et al.
PubMed:7871041
MGI:J:15468
Psychopharmacology (Berl) 112(2-3):352-8
1993
Genetics of age-related hearing loss in mice: I. Inbred and F1 hybrid strains.
Erway LC , et al.
PubMed:8458745
MGI:J:11837
Hear Res 65(1-2):125-32
1992
Dietary obesity in nine inbred mouse strains.
West DB , et al.
PubMed:1621856
MGI:J:1348
Am J Physiol 262(6 Pt 2):R1025-32
1990
Deficiency of the murine fifth complement component (C5). A 2-base pair gene deletion in a 5'-exon.
Wetsel RA , et al.
PubMed:2303408
MGI:J:23983
J Biol Chem 265(5):2435-40
1989
Independence of uniphasic and biphasic audiogenic seizure progressions in mice.
Reid HM , et al.
PubMed:2590151
MGI:J:27065
Behav Neural Biol 52(3):417-21
1987
The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency.
Wheat WH , et al.
PubMed:3572304
MGI:J:8690
J Exp Med 165(5):1442-7
1984
Spontaneous calcified tongue lesions in DBA mice.
Matsushima Y , et al.
PubMed:6519193
MGI:J:166811
Jikken Dobutsu 33(4):539-42
1983
Genetics of beta-2 microglobulin in the mouse.
Michaelson J , et al.
PubMed:6187676
MGI:J:7014
Immunogenetics 17(3):219-60
1979
Genetic defect in secretion of complement C5 in mice.
Ooi YM , et al.
PubMed:492335
MGI:J:6214
Nature 282(5735):207-8
1975
Heritability of the phytohemagglutinin responsiveness of lymphocytes and its relationship to leukemogenesis.
Heiniger HJ , et al.
PubMed:163691
MGI:J:22608
Cancer Res 35(3):825-31
1973
Genetic and biochemical studies of the adrenal lipid depletion phenotype in mice.
Doering CH , et al.
PubMed:4348256
MGI:J:5333
Biochem Genet 8(1):101-11
1972
Genetic relationships between inbred strains of mice.
Taylor BA , et al.
PubMed:5031317
MGI:J:24288
J Hered 63(2):83-6
1968
Reticulum cell neoplasm, type B, or the Hodgkin's-like lesion of the mouse.
Dunn TB , et al.
PubMed:4869134
MGI:J:2417
J Natl Cancer Inst 40(4):771-821
1967
Audiogenic seizures in eleven mouse strains.
Fuller JL , et al.
PubMed:6055327
MGI:J:24264
J Hered 58(3):135-40
1967
Deficiency of the fifth component of complement in mice with an inherited complement defect.
Nilsson UR , et al.
PubMed:4959665
MGI:J:5016
J Exp Med 125(1):1-16
1952
COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice
International Nomenclature Committee , et al.
PubMed:14945054
MGI:J:166288
Cancer Res 12(8):602-13
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基因分型和繁育
基因分型 基因分型相关资源>
Allele Symbol Taar1 rs33645709-SEQ
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Dilute Brown

Related Genotype: a/a Tyrp1b/Tyrp1b Myo5ad/Myo5ad

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