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品系详情
众所周知,BALB/c 小鼠注射矿物油后产生浆细胞瘤,此为单克隆抗体产生的基础。尽管尚未检查所有 BALB/c 亚系的浆细胞瘤诱导情况,但是通过 Andervont (An) 谱系(包括 BALB/cByJ)获得的亚系通常易感,而通过 BALB/cJ 获得的亚系则具有抗性(请参见:Potter M, 1985)。在正常情况下,此品系的乳腺肿瘤发病率较低,但接种经 MMTV+ C3H 小鼠孵育的乳腺肿瘤病毒后,肿瘤数量显著增加,且发病周龄提前。BALB/c 小鼠在生命后期会出现其他癌症,包括网状肿瘤、原发性肺癌和肾肿瘤。在 BALB/cJ 和 BALB/cByJ 亚系中,均观察到由各种外分泌腺的肌上皮细胞引起的罕见自发性肌上皮瘤。研究发现,该品系易感染单核细胞增生李斯特菌,雌鼠感染后至死亡的中位时间为 3 天 (Cheers and McKenzie, 1978)。
White 等人报道了 4 个品系中硫乙醇酸盐培养基诱导的腹膜白细胞募集差异。总白细胞募集的反应由强到弱依次为:C57BL/6J > BALB/c > CD1 > 129X1/SvJ。研究还发现,在反应时间线和受影响最大的细胞类型方面也存在差异。
PLP180-199 免疫 BALB/c 小鼠出现非典型性实验性自身免疫性脑脊髓炎 (experimental autoimmune encephalomyelitis, EAE),其易感性由感染位置决定。对于脊髓感染,有 60-70% 的小鼠出现病理性病变,而对于大脑和小脑感染,则全部 (100%) 小鼠均出现严重病变。 在部分 BALB/cJ 雌鼠中观察到背腹侧阴道膈,可能导致雌鼠无生育能力。(Cunliffe-Beamer T, Lab Anim Sci, 1976)
BALB/c 小鼠易患营养不良性心脏钙质沉着症(心脏组织矿化)。Steven Taffet 博士实验室的一项研究报告比较了杰克森实验室提供的 BALB/cByJBALB/cJ 小鼠,BALB/cByJ 小鼠(44/49;5 周龄时为 90%)表现出的钙质沉积发病率和严重程度高于 BALB/cJ(1/6;5 周龄时为 17%)或其他 BALB/c 亚系小鼠 [Glass et al. 2013 Comp Med 63: 29 (PMID:23561935)]。
小鼠通常会出现黄色毛发,尤其是生殖器周围(可能是排尿污渍造成的),并可能伴随局部脱毛,在老年小鼠中该现象更为明显。
品系建立
此品系是 BALB(Bagg 白化小鼠)的亚系,最初的 BALB 品系由 MacDowell 在冷泉港饲养,最后送至德克萨斯州大学的 G.D. Snell。1932 年,Snell 将 F26 代小鼠带到杰克森实验室。1937-1939 年间,Snell 带来的 BALB/c 小鼠被分为三个分支谱系,即 Andervont (BALB/cAn)、Scott (BALB/cSc) 和 Green (BALB/cGn)。1941 年,BALB/cSc 谱系在 F41 代最终变为 BALB/cJ。
参考文献
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当使用该小鼠品系发表文献时,请引用原始文献,并在材料方法中提供该品系的品系货号:JAX stock#000651


2017

Complete overview of protein-inactivating sequence variations in 36 sequenced mouse inbred strains.

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MGI:J:244295

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2004

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1978

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1971

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1970

Genetic transmission of viruses that incite mammary tumor in mice.

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MGI:J:24803
Proc Natl Acad Sci U S A 67(1):377-84
其他参考文献
当使用该小鼠品系发表文献时,请引用原始文献,并在材料方法中提供该品系的品系货号:JAX stock#000651
2014

Deletion of IL-4Ralpha in the BALB/c mouse is associated with altered lesion topography and susceptibility to experimental autoimmune encephalomyelitis.

Orian JM , et al.

PubMed:25427822
MGI:J:220802
Autoimmunity:1-14
2013

Spontaneous cardiac calcinosis in BALB/cByJ mice.

Glass AM , et al.

PubMed:23561935
MGI:J:307779
Comp Med 63(1):29-37
2009

Comparison of allergic lung disease in three mouse strains after systemic or mucosal sensitization with ovalbumin antigen.

Zhu W , et al.

PubMed:19224206
MGI:J:146790
Immunogenetics 61(3):199-207
2008

Low sociability is associated with reduced size of the corpus callosum in the BALB/cJ inbred mouse strain.

Fairless AH , et al.

PubMed:18662677
MGI:J:138841
Brain Res 1230:211-7
2005

Treatment of murine Th1- and Th2-mediated inflammatory bowel disease with NF-kappa B decoy oligonucleotides.

Fichtner-Feigl S , et al.

PubMed:16239967
MGI:J:145688
J Clin Invest 115(11):3057-71
2005

The allergy adjuvant effect of particles - genetic factors influence antibody and cytokine responses.

Nygaard UC , et al.

2003

Allergen-induced airway disease is mouse strain dependent.

Whitehead GS , et al.

PubMed:12626335
MGI:J:84265
Am J Physiol Lung Cell Mol Physiol 285(1):L32-42
2002

Retinal degeneration mutants in the mouse.

Chang B , et al.

PubMed:11853768
MGI:J:75095
Vision Res 42(4):517-25
2002

Home cage activity and behavioral performance in inbred and hybrid mice.

Tang X , et al.

PubMed:12429418
MGI:J:80398
Behav Brain Res 136(2):555-69
2001

Measuring normal and pathological anxiety-like behaviour in mice: a review.

Belzung C , et al.

PubMed:11682105
MGI:J:72742
Behav Brain Res 125(1-2):141-9
2000

Quantitative trait loci controlling allergen-induced airway hyperresponsiveness in inbred mice.

Ewart SL , et al.

PubMed:11017920
MGI:J:66641
Am J Respir Cell Mol Biol 23(4):537-45
1998

Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11.

Roberts JE , et al.

PubMed:9720874
MGI:J:49726
Mol Microbiol 29(2):581-91
1992

Pre-B lymphocyte-specific transcriptional control of the mouse VpreB gene.

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PubMed:1730257
MGI:J:2014
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1991

Myoepitheliomas in inbred laboratory mice.

Sundberg JP , et al.

PubMed:1719689
MGI:J:22767
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1990

Atherosclerosis susceptibility differences among progenitors of recombinant inbred strains of mice.

Paigen B , et al.

PubMed:2317166
MGI:J:22615
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1989

Deficiency of the corpus callosum: incomplete penetrance and substrain differentiation in BALB/c mice.

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PubMed:2703941
MGI:J:138843
J Neurogenet 5(1):61-76
1987

Differential susceptibility to actively induced experimental allergic encephalomyelitis and experimental allergic orchitis among BALB/c substrains.

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PubMed:2446778
MGI:J:149656
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1986

Differences in susceptibility of inbred mice to Bacillus anthracis.

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PubMed:3081444
MGI:J:8197
Infect Immun 51(3):795-800
1985

Some unusual genetic characteristics of BALB/c and evidence for genetic variation among BALB/c substrains.

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PubMed:3899524
MGI:J:24307
Curr Top Microbiol Immunol 122:9-18
1984

Hippocampal lamination defect = Hld.

Nowakowski RS , et al.

PubMed:
MGI:J:13989
Mouse News Lett 71:35
1984

The mode of inheritance of a defect in lamination in the hippocampus of BALB/c mice.

Nowakowski RS , et al.

PubMed:6536729
MGI:J:7947
J Neurogenet 1(3):249-58
1982

Evidence for genetic control of microwave-induced augmentation of complement receptor-bearing B lymphocytes.

Schlagel CJ , et al.

PubMed:6980940
MGI:J:6835
J Immunol 129(4):1530-3
1976

Vaginal septa in mice: incidence, inheritance, and effect on reproductive, performance.

Cunliffe-Beamer TL , et al.

PubMed:1018474
MGI:J:24296
Lab Anim Sci 26(6 Pt 1):895-8
1976

Differences in tumor incidence in two substrains of Claude BALB/c (BALB/cfCd) mice, emphasizing renal, mammary, pancreatic, and synovial tumors.

Sass B , et al.

PubMed:185454
MGI:J:24705
Lab Anim Sci 26(5):736-41
1972

Genetic relationships between inbred strains of mice.

Taylor BA , et al.

PubMed:5031317
MGI:J:24288
J Hered 63(2):83-6
1971

Reticulosarcoma and amyloid development in BALB/c mice inoculated with syngeneic cells from young and old donors.

Ebbesen P , et al.

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MGI:J:24297
J Natl Cancer Inst 47(6):1241-5
1952

COMMITTEE on Standardized Nomenclature for Inbred Strains of Mice

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等位基因参考文献






基因分型和繁育
Allele Symbol GAL Panel
Allele Specific Protocols
  
Allele Symbol H2<d>-EP
Allele Specific Protocols
  
此品系繁育表现良好。
繁育策略
同胞兄弟姐妹交配
外观
被毛颜色
详情

 

albino

Related Genotype: A/A

Tyrp1b/Tyrp1b Tyrc/Tyrc

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000651
BALBc
肿瘤、免疫学、生理学、核医学研究、单克隆抗体制备